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National Glaucoma Research - Current Awards
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Michael Anderson, Ph.D.
University of Iowa
Iowa City, IA
Title: Genetics of Central Corneal Thickness in Mice
Non-Technical Title: Understanding genes that control corneal thickness
Acknowledgements: Recipient of the Thomas R. Lee Award for glaucoma research
Duration: April 1, 2007 - March 31, 2009
Award Type: Standard
$90,000 |
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Corneal thickness has been implicated in risk for glaucoma. This study seeks to determine whether corneal thickness is genetically controlled.
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Teri Belecky-Adams, Ph.D.
Trustees of Indiana University
Indianapolis, IN
Title: Bmp7 and glaucoma
Non-Technical Title: The role of growth factor Bmp7 in gliosis and ganglion cell survival
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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This study will focus on understanding the role of a growth factor, Bmp7, in both the increased survival of ganglion cells and the disruptive changes the glial cells undergo during glaucoma.
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Milam Brantley, M.D., Ph.D.
Washington University
St. Louis, MO
Title: Nmnat1 as a neuroprotective agent in murine glaucoma
Non-Technical Title: Using neuroprotective genes to limit damage to nerve cells in the eye
Duration: April 1, 2006 - March 31, 2009
Award Type: Standard
$90,000 |
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The purpose of this study is to evaluate the ability of overexpression of Nmnat1 to slow axonal degeneration in two mouse models of optic neuropathy.
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David Calkins, Ph.D.
Vanderbilt University Medical Center
Nasville, TN
Title: TRPV1: A Novel Neuroprotective Target in Glaucoma
Non-Technical Title: Targeting Neurobiological Sensitivity to Pressure in Glaucoma
Acknowledgements: Recipient of the Thomas R. Lee award for National Glaucoma Research
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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This research is aimed at understanding how optic nerve fibers respond to eye pressure and whether blunting this response could prevent vision loss in glaucoma. The study will also help identify new drugs to reduce optic nerve loss in glaucoma by making its fibers insensitive to eye pressure.
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Dong Chen, M.D., Ph.D.
The Schepens Eye Research Institute
Boston, MA
Title: Astroglial Contributions to Glaucoma
Non-Technical Title: Effects of nerve damage on supporting cells in glaucoma
Duration: April 1, 2007 - March 31, 2009
Award Type: Standard
$90,000 |
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In the present application, we hypothesize that responses retinal astroglial cells are directly responsible for glaucoma-induced optic nerve damage and retinal ganglion cell death by producing neurotoxic agents, triggering inflammation, and generating an inhospitable environment.
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Dharamainder Choudhary
University of Connecticut Health Center
Farmington, CT
Title: Mechanistic Effects of CYP1B1 Variations in POAG
Non-Technical Title: Understanding the molecular role of a genetic risk factor for glaucoma
Duration: April 1, 2007 - March 31, 2009
Award Type: Standard
$90,000 |
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This team of investigators hypothesizes that the CYP1B1 mutations exert a regulatory influence on other genes linked to risk of developing glaucoma. Ultimately this research will help in assessing the level of risk present in patients with family histories of glaucoma.
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Mortimer Civan, M.D.
University of Pennsylvania
Philadelphia, PA
Title: Pannexin regulation of aqueous humor inflow and outflow
Non-Technical Title: Can pressure in the eye be reduced by altering release of ATP through newly-identified pannexin channels?
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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The only approach proven to delay the onset and slow the progression of glaucoma is to lower eye pressure. The purine substances adenosine triphosphate (ATP) and adenosine (formed from ATP) are normally produced by cells in the eye, and participate in regulating eye pressure. The aim of this research is to identify how ATP is released at the two surfaces of the ciliary epithelium and also by cells of the aqueous humor outflow pathway, and to use this information to develop a new strategy for lowering eye pressure.
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Jamie Craig, Ph.D.
Flinders University of South Australia
Adelaide, Australia
Title: Genome Wide Association studies in Glaucoma using equimolar DNA pooling
Non-Technical Title: Investigation of common genetic risk factors in glaucoma
Acknowledgements: Recipient of the Thomas R. Lee Award for glaucoma research
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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This research will identify common genetic markers that lead to glaucoma. The scientists will compare people with and without glaucoma to determine common gene variations and identify multiple genetic risk factors. They will prioritize genomic regions important in glaucoma. Understanding genetic factors for glaucoma could lead to earlier and better treatment for those at high risk and reduce the need for treatment for those at lower risk.
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Adriana Di Polo, Ph.D.
University of Montreal
Montreal, Canada
Title: Novel drug-based neuroprotective therapies for glaucoma
Non-Technical Title: Novel neuroprotective strategies for glaucoma.
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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This study will investigate the clinical potential of galantamine, a member of the acetylcholinesterase family, for the treatment of glaucoma. The study may lead to more effective drug-based therapies for treatment, and provide insight for the design of small molecule neuroprotective compounds with high specificity and few side effects.
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C. Ethier, Ph.D.
Imperial College London
London, England
Title: Suitability of Hydrostatic Pressure Model for Studying Glaucoma
Non-Technical Title: Suitable Models for Glaucoma Research
Acknowledgements: Recipient of the Thomas R. Lee award for National Glaucoma Research
Duration: April 1, 2008 - March 31, 2010
Award Type: Standard
$100,000 |
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It has been previously shown that pressure has important effects on nerve cells in the eye. The way the pressure was applied to the cells in these previous studies may not be suitable for studying what occurs in glaucoma. This project will study whether this way of applying pressure to cells is useful for understanding the response of cells in glaucoma. They will repeat previous experiments, but will remove possible confounding effects. They will also measure oxygen levels and pH near the cells in a novel way that will help determine if the cells are being inadvertently exposed to a toxic environment in these experiments.
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Last Reviewed On: 09/26/08
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